Mitochondrial DNA Haplogroups and Neurocognitive Impairment During HIV Infection.

ABSTRACT:

Background

Neurocognitive impairment (NCI) remains an important complication in persons infected with human immunodeficiency virus (HIV). Ancestry-related mitochondrial DNA (mtDNA) haplogroups have been associated with outcomes of HIV infection and combination antiretroviral therapy (CART), and with neurodegenerative diseases. We hypothesize that mtDNA haplogroups are associated with NCI in HIV-infected adults and performed a genetic association study in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) cohort.

Methods

CHARTER is an observational study of ambulatory HIV-infected adults. Haplogroups were assigned using mtDNA sequence, and principal components were derived from ancestry-informative nuclear DNA variants. Outcomes were cross-sectional global deficit

SUBMITTER: Hulgan T 

PROVIDER: S-EPMC4599391 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature