Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success.

ABSTRACT:

Background

Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF.

Methods and results

We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 6

SUBMITTER: Choi EK 

PROVIDER: S-EPMC4599462 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature