Association between maternal HIV infection and low birth weight and prematurity: a meta-analysis of cohort studies.

ABSTRACT:

Background

To assess the association between maternal human immunodeficiency virus (HIV) infection and low birth weight (LBW)/prematurity (PTD), we conducted a meta-analysis of cohort studies of HIV infected and uninfected women.

Methods

Several English and Chinese databases were searched (updated to May 2015) to find the studies reporting infant outcomes associated with exposure to maternal HIV infection during pregnancy. Relevant articles were manually selected based on several inclusion and exclusion criteria.

Results

Fifty-two cohort studies including 15,538 (for LBW) and 200,896 (for PTD) HIV infected women met the inclusion criteria. There was significant heterogeneity among studies for maternal HIV infection associated with LBW/PTD (I(2) = 71.7%, P < 0.05, and

SUBMITTER: Xiao PL 

PROVIDER: S-EPMC4599647 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature