Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington's disease.

ABSTRACT: Immunotherapy, both active and passive, is increasingly recognized as a powerful approach to a wide range of diseases, including Alzheimer's and Parkinson's. Huntington's disease (HD), an autosomal dominant disorder triggered by misfolding of huntingtin (HTT) protein with an expanded polyglutamine tract, could also benefit from this approach. Individuals can be identified genetically at the earliest stages of disease, and there may be particular benefits to a therapy that can target peripheral tissues in addition to brain. In this active vaccination study, we first examined safety and immunogenicity for a broad series of peptide, protein and DNA plasmid immunization protocols, using fragment (R6/1), and knock-in (zQ175) models. No safety issues were found. The strongest and most uniform im

SUBMITTER: Ramsingh AI 

PROVIDER: S-EPMC4599676 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature