A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease.

ABSTRACT:

Background

Phenotypes of eosinophilic esophagitis (EoE) are not well-characterized.

Objective

To describe clinical features of patients with EoE with predefined phenotypes, determine predictors of these phenotypes, and make inferences about the natural history of EoE.

Design

Retrospective study.

Setting

Tertiary-care center.

Patients

Incident EoE cases from 2001 to 2011 that met consensus diagnostic guidelines.

Intervention

Review of records.

Main outcome measurements

Endoscopic phenotypes, including fibrostenotic, inflammatory, or mixed. Other groups of clinical characteristics examined included atopy, level of esophageal eosinophilia, and age of symptom onset. Multinomial logistic regression assessed predictors of phenotype status.

Res

SUBMITTER: Dellon ES 

PROVIDER: S-EPMC4599711 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature