Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population.

ABSTRACT:

Background

Nuclear receptor coactivator-3 (NCOA3) is involved in various physiological processes. Emerging evidence from previous studies using animal models suggests that the NCOA3 gene (NCOA3) plays a critical role in lipid metabolism as well as adipogenesis and obesity. The present study aims to investigate the association between NCOA3 SNPs and dyslipidemia in the Chinese Han population.

Methods

Five hundred and twenty-nine (529) Chinese Han subjects were recruited. Four tag SNPs (rs2425955G > T, rs6066394T > C, rs10485463C > G, and rs6094753G > A) in NCOA3, selected from the HapMap website, were genotyped using MALDI-TOF mass spectrometry. Data analysis was performed using SPSS 16.0, SNPStats and haploview 4.2.

Results

Four SNPs (rs2425955, rs6066394, rs10485463,

SUBMITTER: Yu M 

PROVIDER: S-EPMC4599759 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature