Peptide spectra in Wilms tumor that associate with adverse outcomes.

ABSTRACT:

Background

The 2013 Children's Oncology Group (COG) blueprint for renal tumor research challenges investigators to develop new, risk-specific biological therapies for unfavorable histology and higher-risk Wilms tumor (WT) in an effort to close a persistent survival gap and to reduce treatment toxicities. As an initial response to this call from the COG, we used imaging mass spectrometry to determine peptide profiles of WT associated with adverse outcomes.

Materials and methods

We created a WT tissue microarray containing 2-mm punches of formalin-fixed, paraffin-embedded specimens archived from 48 sequentially treated WT patients at our institutions. Imaging mass spectrometry was performed to compare peptide spectra between three patient groups as follows: unfavorable versus

SUBMITTER: Murphy AJ 

PROVIDER: S-EPMC4599776 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature