The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities.

ABSTRACT: Significant advances have been made over the past 25 years in our understanding of the most common adult solid tumors such as breast, colon, lung and prostate cancer. Much less is known about childhood solid tumors because they are rare and because they originate in developing organs during fetal development, childhood and adolescence. It can be very difficult to study the cellular origins of pediatric solid tumors in developing organs characterized by rapid proliferative expansion, growth factor signaling, developmental angiogenesis, programmed cell death, tissue reorganization and cell migration. Not only has the etiology of pediatric cancer remained elusive because of their developmental origins, but it also makes it more difficult to treat. Molecular targeted therapeutics that alter de

SUBMITTER: Stewart E 

PROVIDER: S-EPMC4600003 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature