Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers.

ABSTRACT:

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An estimated one-third of the world's population is currently latently infected with Mycobacterium tuberculosis. Latent M. tuberculosis infection (LTBI) progresses into active tuberculosis (TB) disease in ~5 to 10% of infected individuals. Diagnostic and prognostic biomarkers to monitor disease progression are urgently needed to ensure better care for TB patients and to decrease the spread of TB. Biomarker development is primarily based on transcriptomics. Our understanding of biology combined with evolving technical advances in high-throughput techniques led us to investigate the possibility of additional platforms (epigenetics and proteomics) in the quest to (i) understand the biology of the TB host response and (ii) search for multiplatform biosignatures in TB. We eng

SUBMITTER: Esterhuyse MM 

PROVIDER: S-EPMC4600108 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature