Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.

ABSTRACT:

Unlabelled

Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined. Nef interferes with host cell actin dynamics to restrict T lymphocyte responses to chemokine stimulation and T cell receptor engagement. This relies on the assembly of a labile multiprotein complex including the host kinase PAK2 that Nef usurps to phosphorylate and inactivate the actin-severing factor cofilin. Components of the exocyst complex (EXOC), an octameric protein complex involved in vesicular transport and actin remodeling, were recently reported to interact with Nef via the same molecular surface that mediates PAK2 association. Exploring the functional relevance of EXOC in Nef-

SUBMITTER: Imle A 

PROVIDER: S-EPMC4600113 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature