The Human Skin Microbiome Associates with the Outcome of and Is Influenced by Bacterial Infection.

ABSTRACT:

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The influence of the skin microbiota on host susceptibility to infectious agents is largely unexplored. The skin harbors diverse bacterial species that may promote or antagonize the growth of an invading pathogen. We developed a human infection model for Haemophilus ducreyi in which human volunteers are inoculated on the upper arm. After inoculation, papules form and either spontaneously resolve or progress to pustules. To examine the role of the skin microbiota in the outcome of H. ducreyi infection, we analyzed the microbiomes of four dose-matched pairs of "resolvers" and "pustule formers" whose inoculation sites were swabbed at multiple time points. Bacteria present on the skin were identified by amplification and pyrosequencing of 16S rRNA genes. Nonmetric multidimen

SUBMITTER: van Rensburg JJ 

PROVIDER: S-EPMC4600114 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature