A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections.

ABSTRACT:

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Nontyphoidal Salmonella enterica (NTS) infections are a major burden to global public health, as they lead to diseases ranging from gastroenteritis to systemic infections and there is currently no vaccine available. Here, we describe a highly effective component vaccine against S. enterica serovar Typhimurium in both gastroenteritis and systemic murine infection models. We devised an approach to generate supernatants of S. enterica serovar Typhimurium, an organism that is highly abundant in virulence factors. Immunization of mice with this supernatant resulted in dramatic protection against a challenge with serovar Typhimurium, showing increased survival in the systemic model and decreased intestinal pathology in the gastrointestinal model. Protection correlated with spe

SUBMITTER: Ferreira RB 

PROVIDER: S-EPMC4600123 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature