Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions.

ABSTRACT: The accepted paradigm for intestinal-type gastric cancer pathogenesis is a multistep progression from chronic gastritis induced by Helicobacter pylori (H. pylori) to gastric atrophy, intestinal metaplasia, dysplasia and ultimately gastric cancer. The genetic and molecular mechanisms underlying disease progression are still not completely understood as only a fraction of colonized individuals ever develop neoplasia suggesting that bacterial, host and environmental factors are involved. MicroRNAs are noncoding RNAs that may influence H. pylori-related pathology through the regulation of the transcription and expression of various genes, playing an important role in inflammation, cell proliferation, apoptosis and differentiation. Indeed, H. pylori have been shown to modify microRNA expression

SUBMITTER: Libanio D 

PROVIDER: S-EPMC4600186 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature