Molecular adaptation of Lactobacillus plantarum WCFS1 to gallic acid revealed by genome-scale transcriptomic signature and physiological analysis.

ABSTRACT:

Background

Gallic acid (GA) is a model hydroxybenzoic acid that occurs esterified in the lignocellulosic biomass of higher plants. GA displays relevant biological activities including anticancer properties. Owing to its antimicrobial and cellulase-inhibiting activities, GA also imposes constraints to the fermentability of lignocellulosic hydrolysates. In depth-knowledge of the mechanisms used by tolerant microorganisms to adapt to hydroxybenzoic acids would be a step forward to improve the bioavailability of GA or select/engineer production hosts with improved metabolic traits for the bioconversion of pretreated lignocellulosic biomass.

Results

Whole genome transcriptional profiling using DNA microarrays was used to characterize the molecular response of Lactobacillus planta

SUBMITTER: Reveron I 

PROVIDER: S-EPMC4600210 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature