Runs of homozygosity reveal signatures of positive selection for reproduction traits in breed and non-breed horses.

ABSTRACT:

Background

Modern horses represent heterogeneous populations specifically selected for appearance and performance. Genomic regions under high selective pressure show characteristic runs of homozygosity (ROH) which represent a low genetic diversity. This study aims at detecting the number and functional distribution of ROHs in different horse populations using next generation sequencing data.

Methods

Next generation sequencing was performed for two Sorraia, one Dülmen Horse, one Arabian, one Saxon-Thuringian Heavy Warmblood, one Thoroughbred and four Hanoverian. After quality control reads were mapped to the reference genome EquCab2.70. ROH detection was performed using PLINK, version 1.07 for a trimmed dataset with 11,325,777 SNPs and a mean read depth of 12. Stretches with

SUBMITTER: Metzger J 

PROVIDER: S-EPMC4600213 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature