Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation.

ABSTRACT:

Background

The oncogenic transcription factor MYC is pathologically activated in many human malignancies. A paradigm for MYC dysregulation is offered by Burkitt lymphoma, where chromosomal translocations leading to Immunoglobulin gene-MYC fusion are the crucial initiating oncogenic events. However, Burkitt lymphoma cases with no detectable MYC rearrangement but maintaining MYC expression have been identified and alternative mechanisms can be involved in MYC dysregulation in these cases.

Methods

We studied the microRNA profile of MYC translocation-positive and MYC translocation-negative Burkitt lymphoma cases in order to uncover possible differences at the molecular level. Data was validated at the mRNA and protein level by quantitative Real-Time polymerase chain reaction and

SUBMITTER: De Falco G 

PROVIDER: S-EPMC4600215 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature