Transcriptome profile of liver at different physiological stages reveals potential mode for lipid metabolism in laying hens.

ABSTRACT:

Background

Liver is an important metabolic organ that plays a critical role in lipid synthesis, degradation, and transport; however, the molecular regulatory mechanisms of lipid metabolism remain unclear in chicken. In this study, RNA-Seq technology was used to investigate differences in expression profiles of hepatic lipid metabolism-related genes and associated pathways between juvenile and laying hens. The study aimed to broaden the understanding of liver lipid metabolism in chicken, and thereby to help improve laying performance in the poultry industry.

Results

RNA-Seq analysis was carried out on total RNA harvested from the liver of juvenile (n = 3) and laying (n = 3) hens. Compared with juvenile hens, 2567 differentially expressed genes (1082 up-regulated and 1485 down

SUBMITTER: Li H 

PROVIDER: S-EPMC4600267 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature