The effect of temperature on apoptosis and adipogenesis on skeletal muscle satellite cells derived from different muscle types.

ABSTRACT: Satellite cells are multipotential stem cells that mediate postnatal muscle growth and respond differently to temperature based upon aerobic versus anaerobic fiber-type origin. The objective of this study was to determine how temperatures below and above the control, 38°C, affect the fate of satellite cells isolated from the anaerobic pectoralis major (p. major) or mixed fiber biceps femoris (b. femoris). At all sampling times, p. major and b. femoris cells accumulated less lipid when incubated at low temperatures and more lipid at elevated temperatures compared to the control. Satellite cells isolated from the p. major were more sensitive to temperature as they accumulated more lipid at elevated temperatures compared to b. femoris cells. Expression of adipogenic genes, CCAAT/enhancer-bind

SUBMITTER: Harding RL 

PROVIDER: S-EPMC4600383 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature