The airway microbiome in patients with severe asthma: Associations with disease features and severity.

ABSTRACT:

Background

Asthma is heterogeneous, and airway dysbiosis is associated with clinical features in patients with mild-to-moderate asthma. Whether similar relationships exist among patients with severe asthma is unknown.

Objective

We sought to evaluate relationships between the bronchial microbiome and features of severe asthma.

Methods

Bronchial brushings from 40 participants in the Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) study were evaluated by using 16S ribosomal RNA-based methods. Relationships to clinical and inflammatory features were analyzed among microbiome-profiled subjects. Secondarily, bacterial compositional profiles were compared between patients with severe asthma and previously studied healthy co

SUBMITTER: Huang YJ 

PROVIDER: S-EPMC4600429 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature