Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction.

ABSTRACT:

Rationale

The hippocampus is implicated in many of the cognitive impairments observed in conditions such as Alzheimer's disease (AD) and schizophrenia (SCZ). Often, mice are the species of choice for models of these diseases and the study of the relationship between brain and behaviour more generally. Thus, automated and efficient hippocampal-sensitive cognitive tests for the mouse are important for developing therapeutic targets for these diseases, and understanding brain-behaviour relationships. One promising option is to adapt the touchscreen-based trial-unique nonmatching-to-location (TUNL) task that has been shown to be sensitive to hippocampal dysfunction in the rat.

Objectives

This study aims to adapt the TUNL task for use in mice and to test for hippocampus-dependenc

SUBMITTER: Kim CH 

PROVIDER: S-EPMC4600470 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature