The role of 5-HT2C receptors in touchscreen visual reversal learning in the rat: a cross-site study.

ABSTRACT:

Rationale

Reversal learning requires associative learning and executive functioning to suppress non-adaptive responding. Reversal-learning deficits are observed in e.g. schizophrenia and obsessive-compulsive disorder and implicate neural circuitry including the orbitofrontal cortex (OFC). Serotonergic function has been strongly linked to visual reversal learning in humans and experimental animals but less is known about which receptor subtypes are involved.

Objectives

The objectives of the study were to test the effects of systemic and intra-OFC 5-HT2C-receptor antagonism on visual reversal learning in rats and assess the psychological mechanisms underlying these effects within novel touchscreen paradigms.

Methods

In experiments 1-2, we used a novel 3-stimulus task to

SUBMITTER: Alsio J 

PROVIDER: S-EPMC4600472 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature