Cortical Excitability Measured with nTMS and MEG during Stroke Recovery.

ABSTRACT:

Objective

Stroke alters cortical excitability both in the lesioned and in the nonlesioned hemisphere. Stroke recovery has been studied using transcranial magnetic stimulation (TMS). Spontaneous brain oscillations and somatosensory evoked fields (SEFs) measured by magnetoencephalography (MEG) are modified in stroke patients during recovery.

Methods

We recorded SEFs and spontaneous MEG activity and motor threshold (MT) short intracortical inhibition (SICI) and intracortical facilitation (ICF) with navigated TMS (nTMS) at one and three months after first-ever hemispheric ischemic strokes. Changes of MEG and nTMS parameters attributed to gamma-aminobutyrate and glutamate transmission were compared.

Results

ICF correlated with the strength and extent of SEF source areas de

SUBMITTER: Makela JP 

PROVIDER: S-EPMC4600492 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature