Distribution of IL-28B genotypes in patients with hepatitis C and healthy individuals in Jahrom city.

ABSTRACT:

Aim

The purpose of this study was to compare the distribution of interleukin (IL)-28B genotypes between Iranian healthy individuals and patients with chronic hepatitis C based on the genotype.

Background

Polymorphisms in the region of IL-28B gene have been identified as the strongest genetic pretreatment predictor of sustained virological response (SVR) in hepatitis C infection.

Patients and methods

In this study, 147 patients with chronic hepatitis C and 80 healthy individuals were included. The IL-28B rs12979860 and rs8099917 polymorphisms were genotyped by PCR-RFLP method and the frequency of IL-28B polymorphisms with respect to HCV genotypes was also determined.

Results

The frequencies of rs12979860 TT, CC and CT genotypes in the chronic hepatitis C patient

SUBMITTER: Mousavi Nasab SD 

PROVIDER: S-EPMC4600518 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature