Modulation of host lipid metabolism by hepatitis C virus: Role of new therapies.

ABSTRACT: It is well established that hepatitis C virus (HCV) infection and replication relies on host lipid metabolism. HCV proteins interact and associate with lipid droplets to facilitate virion assembly and production. Besides, circulating infective particles are associated with very low-density lipoprotein. On the other hand, higher serum lipid levels have been associated with sustained viral response to pegylated interferon and ribavirin therapy in chronic HCV infection, suggesting a relevant role in viral clearance for host proteins. Host and viral genetic factors play an essential role in chronic infection. Lipid metabolism is hijacked by viral infection and could determine the success of viral replication. Recently development of direct acting antiviral agents has shown a very high efficacy

SUBMITTER: Del Campo JA 

PROVIDER: S-EPMC4600579 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature