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Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is an age-related fatal disease with unknown etiology and no effective treatment. In this study, we show that primary cultures of fibroblasts derived from lung biopsies of IPF patients exhibited (i) accelerated replicative cellular senescence (CS); (ii) high resistance to oxidative-stress-induced cytotoxicity or CS; (iii) a CS-like morphology (even at the proliferative phase); and (iv) rapid accumulation of senescent cells expressing the myofibroblast marker ?-SMA. Our findings suggest that CS could serve as a bridge connecting lung aging and its quite frequent outcome -- pulmonary fibrosis, and be an important player in the disease progression. Consequently, targeting senescent cells offers the potential of being a promising therapeutic approach.

SUBMITTER: Yanai H 

PROVIDER: S-EPMC4600624 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients.

Yanai Hagai H   Shteinberg Albert A   Porat Ziv Z   Budovsky Arie A   Braiman Alex A   Zeische Rolf R   Fraifeld Vadim E VE  

Aging 20150901 9

Idiopathic pulmonary fibrosis (IPF) is an age-related fatal disease with unknown etiology and no effective treatment. In this study, we show that primary cultures of fibroblasts derived from lung biopsies of IPF patients exhibited (i) accelerated replicative cellular senescence (CS); (ii) high resistance to oxidative-stress-induced cytotoxicity or CS; (iii) a CS-like morphology (even at the proliferative phase); and (iv) rapid accumulation of senescent cells expressing the myofibroblast marker α  ...[more]