Effects of oral temazepam on sleep spindles during non-rapid eye movement sleep: A high-density EEG investigation.

ABSTRACT: Benzodiazepines are commonly used medications that alter sleep spindles during non-rapid eye movement (NREM) sleep, however the topographic changes to these functionally significant waveforms have yet to be fully elucidated. This study utilized high-density electroencephalography (hdEEG) to investigate topographic changes in sleep spindles and spindle-range activity caused by temazepam during NREM sleep in 18 healthy adults. After an accommodation night, sleep for all participants was recorded on two separate nights after taking either placebo or oral temazepam 15 mg. Sleep was monitored using 256-channel hdEEG. Spectral analysis and spindle waveform detection of sleep EEG data were performed for each participant night. Global and topographic data were subsequently compared between temazep

SUBMITTER: Plante DT 

PROVIDER: S-EPMC4600644 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature