Gene expression markers of age-related inflammation in two human cohorts.

ABSTRACT:

Introduction

Chronically elevated circulating inflammatory markers are common in older persons but mechanisms are unclear. Many blood transcripts (>800 genes) are associated with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene transcripts statistically mediating, as drivers or responders, the increasing levels of IL6 protein in blood at older ages.

Methods

Blood derived in-vivo RNA from the Framingham Heart Study (FHS, n=2422, ages 40-92 yrs) and InCHIANTI study (n=694, ages 30-104 yrs), with Affymetrix and Illumina expression arrays respectively (>17,000 genes tested), were tested for statistical mediation of the age-IL6 association using resampling techniques, adjusted for confounders and multiple testing.

Results

In FHS, IL6 express

SUBMITTER: Pilling LC 

PROVIDER: S-EPMC4600657 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature