Diagnostic Value of Ceruloplasmin in the Diagnosis of Pediatric Wilson's Disease.

ABSTRACT:

Purpose

Measurement of serum ceruloplasmin level is the first step in screening for Wilson's disease (WD). Despite the rarity of WD in the general population, ceruloplasmin levels are routinely measured through hepatitis screening in both adults and children. Herein, we evaluated the diagnostic value of ceruloplasmin for the diagnosis of WD among children with hepatitis.

Methods

We retrospectively reviewed data on serum ceruloplasmin levels measured as a serologic marker for patients with hepatitis at Asan Medical Center (Seoul, Korea) between from January 2004 to November 2013. The diagnosis of WD was confirmed by the identification of pathogenic variants in the ATP7B gene. To determine the diagnostic accuracy of ceruloplasmin, receiver operation characteristic (ROC) curves

SUBMITTER: Kim JA 

PROVIDER: S-EPMC4600703 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature