Affective mentalizing and brain activity at rest in the behavioral variant of frontotemporal dementia.

ABSTRACT:

Background

bvFTD patients display an impairment in the attribution of cognitive and affective states to others, reflecting GM atrophy in brain regions associated with social cognition, such as amygdala, superior temporal cortex and posterior insula. Distinctive patterns of abnormal brain functioning at rest have been reported in bvFTD, but their relationship with defective attribution of affective states has not been investigated.

Objective

To investigate the relationship among resting-state brain activity, gray matter (GM) atrophy and the attribution of mental states in the behavioral variant of fronto-temporal degeneration (bvFTD).

Methods

We compared 12 bvFTD patients with 30 age- and education-matched healthy controls on a) performance in a task requiring the attr

SUBMITTER: Caminiti SP 

PROVIDER: S-EPMC4600858 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature