Prevention of immediate recurrence of atrial fibrillation with low-dose landiolol after radiofrequency catheter ablation.

ABSTRACT:

Background

Immediate recurrence of atrial fibrillation (AF) after radiofrequency (RF) catheter ablation is commonly observed within 3 d after the procedure. The mechanism and pharmacological management of immediate AF recurrence remain unclear.

Methods

A total of 50 consecutive patients with paroxysmal AF were randomized to receive either low-dose landiolol (landiolol group) or a placebo (placebo group). In the landiolol group, intravenous landiolol (0.5 μg kg(-1) min(-1)) was administered for 3 d after AF ablation.

Results

No serious adverse event associated with RF catheter ablation or landiolol administration was observed. The prevalence of immediate AF recurrence (≤3 d after RF catheter ablation) was significantly lower in the landiolol group than in the placebo g

SUBMITTER: Ishigaki D 

PROVIDER: S-EPMC4600890 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature