Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation.

ABSTRACT: The mechanisms by which the mammalian mitotic spindle is guided to a predefined orientation through microtubule-cortex interactions have recently received considerable interest, but there has been no dynamic model that describes spindle movements toward the preferred axis in human cells. Here, we develop a dynamic model based on stochastic activity of cues anisotropically positioned around the cortex of the mitotic cell and we show that the mitotic spindle does not reach equilibrium before chromosome segregation. Our model successfully captures the characteristic experimental behavior of noisy spindle rotation dynamics in human epithelial cells, including a weak underlying bias in the direction of rotation, suppression of motion close to the alignment axis, and the effect of the aspect rat

SUBMITTER: Corrigan AM 

PROVIDER: S-EPMC4601064 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature