Altered Functional Connectivity Strength in Abstinent Chronic Cocaine Smokers Compared to Healthy Controls.

ABSTRACT: Past research involving cocaine and resting-state functional connectivity (RSFC) has shown altered functional connectivity within the frontal and between the frontal and other cortical and subcortical brain regions in chronic users of cocaine. However, there have been discrepancies in literature regarding the relationship between RSFC between brain regions and cocaine use behavior. This study explored the RSFC between brain regions in cocaine smokers abstinent from cocaine use for 72 h and healthy controls. Also, the relationship between RSFC between brain regions and various cocaine use measures (cocaine use duration; frequency, and money spent on cocaine/week) was examined. Twenty chronic cocaine users and 17 controls completed a resting-state scan and an anatomical MPRAGE scan. Group in

SUBMITTER: Ray S 

PROVIDER: S-EPMC4601553 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature