The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

ABSTRACT: The structure of death receptor 4 (DR4) in complex with TNF-related apoptosis-inducing ligand (TRAIL) has been determined at 3 Å resolution and compared with those of previously determined DR5-TRAIL complexes. Consistent with the high sequence similarity between DR4 and DR5, the overall arrangement of the DR4-TRAIL complex does not differ substantially from that of the DR5-TRAIL complex. However, subtle differences are apparent. In addition, solution interaction studies were carried out that show differences in the thermodynamics of binding DR4 or DR5 with TRAIL.

SUBMITTER: Ramamurthy V 

PROVIDER: S-EPMC4601591 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature