Cognitive Effort and Schizophrenia Modulate Large-Scale Functional Brain Connectivity.

ABSTRACT: Schizophrenia (SZ) is characterized by cognitive dysfunction and disorganized thought, in addition to hallucinations and delusions, and is regarded a disorder of brain connectivity. Recent efforts have been made to characterize the underlying brain network organization and interactions. However, to which degree connectivity alterations in SZ vary across different levels of cognitive effort is unknown. Utilizing independent component analysis (ICA) and methods for delineating functional connectivity measures from functional magnetic resonance imaging (fMRI) data, we investigated the effects of cognitive effort, SZ and their interactions on between-network functional connectivity during 2 levels of cognitive load in a large and well-characterized sample of SZ patients (n = 99) and healthy in

SUBMITTER: Brandt CL 

PROVIDER: S-EPMC4601701 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature