Disintegration of Sensorimotor Brain Networks in Schizophrenia.

ABSTRACT:

Background

Schizophrenia is a severe mental disorder associated with derogated function across various domains, including perception, language, motor, emotional, and social behavior. Due to its complex symptomatology, schizophrenia is often regarded a disorder of cognitive processes. Yet due to the frequent involvement of sensory and perceptual symptoms, it has been hypothesized that functional disintegration between sensory and cognitive processes mediates the heterogeneous and comprehensive schizophrenia symptomatology.

Methods

Here, using resting-state functional magnetic resonance imaging in 71 patients and 196 healthy controls, we characterized the standard deviation in BOLD (blood-oxygen-level-dependent) signal amplitude and the functional connectivity across a range o

SUBMITTER: Kaufmann T 

PROVIDER: S-EPMC4601711 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature