Impact of MR Acquisition Parameters on DTI Scalar Indexes: A Tractography Based Approach.

ABSTRACT: Acquisition parameters play a crucial role in Diffusion Tensor Imaging (DTI), as they have a major impact on the values of scalar measures such as Fractional Anisotropy (FA) or Mean Diffusivity (MD) that are usually the focus of clinical studies based on white matter analysis. This paper presents an analysis on the impact of the variation of several acquisition parameters on these scalar measures with a novel double focus. First, a tractography-based approach is employed, motivated by the significant number of clinical studies that are carried out using this technique. Second, the consequences of simultaneous changes in multiple parameters are analyzed: number of gradient directions, b-value and voxel resolution. Results indicate that the FA is most affected by changes in the number of gra

SUBMITTER: Barrio-Arranz G 

PROVIDER: S-EPMC4601730 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature