Defining order and timing of mutations during cancer progression: the TO-DAG probabilistic graphical model.

ABSTRACT: Somatic mutations arise and accumulate both during tumor genesis and progression. However, the order in which mutations occur is an open question and the inference of the temporal ordering at the gene level could potentially impact on patient treatment. Thus, exploiting recent observations suggesting that the occurrence of mutations is a non-memoryless process, we developed a computational approach to infer timed oncogenetic directed acyclic graphs (TO-DAGs) from human tumor mutation data. Such graphs represent the path and the waiting times of alterations during tumor evolution. The probability of occurrence of each alteration in a path is the probability that the alteration occurs when all alterations prior to it have occurred. The waiting time between an alteration and the subsequent is

SUBMITTER: Lecca P 

PROVIDER: S-EPMC4602157 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature