Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion.

ABSTRACT: Tumor cell invasion requires the molecular and physical adaptation of both the cell and its microenvironment. Here we show that tumor cells are able to switch between the use of microvesicles and invadopodia to facilitate invasion through the extracellular matrix. Invadopodia formation accompanies the mesenchymal mode of migration on firm matrices and is facilitated by Rac1 activation. On the other hand, during invasion through compliant and deformable environments, tumor cells adopt an amoeboid phenotype and release microvesicles. Notably, firm matrices do not support microvesicle release, whereas compliant matrices are not conducive to invadopodia biogenesis. Furthermore, Rac1 activation is required for invadopodia function, while its inactivation promotes RhoA activation and actomyosin

SUBMITTER: Sedgwick AE 

PROVIDER: S-EPMC4602187 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature