Prophylactic antibiotic regimens in tumour surgery (PARITY): a pilot multicentre randomised controlled trial.

ABSTRACT:

Objective

Clinical studies of patients with bone sarcomas have been challenged by insufficient numbers at individual centres to draw valid conclusions. Our objective was to assess the feasibility of conducting a definitive multi-centre randomised controlled trial (RCT) to determine whether a five-day regimen of post-operative antibiotics, in comparison to a 24-hour regimen, decreases surgical site infections in patients undergoing endoprosthetic reconstruction for lower extremity primary bone tumours.

Methods

We performed a pilot international multi-centre RCT. We used central randomisation to conceal treatment allocation and sham antibiotics to blind participants, surgeons, and data collectors. We determined feasibility by measuring patient enrolment, completeness of follow

SUBMITTER: PARITY Investigators 

PROVIDER: S-EPMC4602191 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature