Determining Associations between Human Diseases and non-coding RNAs with Critical Roles in Network Control.

ABSTRACT: Deciphering the association between life molecules and human diseases is currently an important task in systems biology. Research over the past decade has unveiled that the human genome is almost entirely transcribed, producing a vast number of non-protein-coding RNAs (ncRNAs) with potential regulatory functions. More recent findings suggest that many diseases may not be exclusively linked to mutations in protein-coding genes. The combination of these arguments poses the question of whether ncRNAs that play a critical role in network control are also enriched with disease-associated ncRNAs. To address this question, we mapped the available annotated information of more than 350 human disorders to the largest collection of human ncRNA-protein interactions, which define a bipartite network o

SUBMITTER: Kagami H 

PROVIDER: S-EPMC4602215 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature