Characterization of plasma protein binding dissociation with online SPE-HPLC.

ABSTRACT: A novel parameter of relative recovery (R re) was defined and determined by online SPE-HPLC to characterize plasma protein binding (PPB) kinetics of highly plasma binding drugs. The proportional relationship of R re with k off of PPB has been established with a new SPE model. A rapid, easy to use method could potentially be used to categorize PK properties of the drug candidates in the decision process of drug discovery and development.

SUBMITTER: Li P 

PROVIDER: S-EPMC4602217 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature