Connexin 43 expression predicts poor progression-free survival in patients with non-muscle invasive urothelial bladder cancer.

ABSTRACT:

Objectives

To evaluate the protein expression of connexin 43 (Cx43) in primary urothelial bladder cancer and test its association with the histopathological characteristics and clinical outcome.

Methods

A tissue microarray containing 348 tissue samples from 174 patients with primary urothelial carcinomas of the bladder was immunohistochemically stained for Cx43. The intensity of staining was semiquantitatively evaluated (score 0, 1+, 2+), and the association with clinicopathological features was assessed. Univariable and multivariable analyses were performed to identify predictors for progression-free survival (PFS).

Results

Membranous Cx43 immunoreactivity was detected in 118 (67.8%) of 174 analysable urothelial carcinomas, of which 31 (17.8%) showed even a strong (s

SUBMITTER: Poyet C 

PROVIDER: S-EPMC4602233 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature