Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women.

ABSTRACT:

Objectives

We examined the influence of CYP1A1 A4889G and T6235C polymorphisms on the risk of sporadic breast cancer.

Methods

DNA from 742 sporadic breast cancer patients and 742 controls was analyzed using the polymerase chain reaction, followed by the restriction fragment length polymorphism technique.

Results

More patients had the CYP1A1 4889AG+GG genotype compared to controls (29.0% versus 23.2%, p=0.004). The G allele carriers had a 1.50-fold increased risk (95% CI: 1.14-1.97) of sporadic breast cancer compared to the other study participants. The frequency of the 4889AG+GG genotype among the Caucasian patients was higher than in the non-Caucasian patients (30.4% versus 20.2%, p=0.03) and controls (30.4% versus 23.2%, p=0.002). Caucasians and G allele carriers ha

SUBMITTER: Oliveira CB 

PROVIDER: S-EPMC4602382 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature