Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.

ABSTRACT:

Objectives

Early identification of patients with infection and at risk of developing severe disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a multicenter setting.

Design

A prospective international multicenter cohort study.

Setting

Seven different emergency departments in Sweden, Canada, and the United States.

Patients

Adult patients with a suspected infection and at least one of three clinical systemic inflammatory response syndrome criteria (excluding leukocyte count).

Intervention

None.

Measurements and main results

Plasma le

SUBMITTER: Linder A 

PROVIDER: S-EPMC4603368 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature