Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease.

ABSTRACT:

Objective

People with Parkinson disease (PD) frequently develop dementia, which is associated with neocortical deposition of alpha-synuclein (α-syn) in Lewy bodies and Lewy neurites. In addition, neuronal loss and deposition of aggregated α-syn also occur in multiple subcortical nuclei that project to neocortical, limbic, and basal ganglia regions. Therefore, we quantified regional deficits in innervation from these PD-affected subcortical nuclei, by measuring the neurotransmitters and neurotransmitter transporter proteins originating from projections of dopaminergic neurons in substantia nigra pars compacta, serotonergic neurons in dorsal raphé nuclei, noradrenergic neurons in locus coeruleus, and cholinergic neurons in nucleus basalis of Meynert.

Methods

High-performance l

SUBMITTER: Buddhala C 

PROVIDER: S-EPMC4603378 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature