Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy.

ABSTRACT:

Objective

To investigate anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP).

Methods

Sera from 50 consecutive CIDP patients diagnosed in our clinic, 32 patients with multiple sclerosis, 40 patients with other neuropathies including 26 with Guillain-Barré syndrome (GBS)/Fisher syndrome, and 30 healthy controls were measured for anti-NF antibodies by flow cytometry using HEK293 cell lines stably expressing human NF155 or NF186. Four additional CIDP patients with anti-NF155 antibodies referred from other clinics were enrolled for clinical characterization.

Results

The positivity rate for anti-NF155 antibodies in CIDP patients was 18% (9/50), who all showed a predominance of IgG4 subclass. No other subjects were positiv

SUBMITTER: Ogata H 

PROVIDER: S-EPMC4603379 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature