Click with a boronic acid handle: a neighboring group-assisted click reaction that allows ready secondary functionalization.

ABSTRACT: The feasibility of a neighboring boronic acid-facilitated facile condensation of an aldehyde is described. This reaction is bio-orthogonal, complete at room temperature within minutes, and suitable for bioconjugation chemistry. The boronic acid group serves the dual purpose of catalyzing the condensation reaction and being a handle for secondary functionalization.

SUBMITTER: Draganov AB 

PROVIDER: S-EPMC4603419 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature