Tex19 and Sectm1 concordant molecular phylogenies support co-evolution of both eutherian-specific genes.

ABSTRACT:

Background

Transposable elements (TE) have attracted much attention since they shape the genome and contribute to species evolution. Organisms have evolved mechanisms to control TE activity. Testis expressed 19 (Tex19) represses TE expression in mouse testis and placenta. In the human and mouse genomes, Tex19 and Secreted and transmembrane 1 (Sectm1) are neighbors but are not homologs. Sectm1 is involved in immunity and its molecular phylogeny is unknown.

Methods

Using multiple alignments of complete protein sequences (MACS), we inferred Tex19 and Sectm1 molecular phylogenies. Protein conserved regions were identified and folds were predicted. Finally, expression patterns were studied across tissues and species using RNA-seq public data and RT-PCR.

Results

We present

SUBMITTER: Bianchetti L 

PROVIDER: S-EPMC4603632 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature