The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles.

ABSTRACT:

Background

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a burgeoning class of natural products with diverse activity that share a similar origin and common features in their biosynthetic pathways. The precursor peptides of these natural products are ribosomally produced, upon which a combination of modification enzymes installs diverse functional groups. This genetically encoded peptide-based strategy allows for rapid diversification of these natural products by mutation in the precursor genes merged with unique combinations of modification enzymes. Thiazole/oxazole-modified microcins (TOMMs) are a class of RiPPs defined by the presence of heterocycles derived from cysteine, serine, and threonine residues in the precursor peptide. TOMMs encompass a

SUBMITTER: Cox CL 

PROVIDER: S-EPMC4603692 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature