Ontology highlight
ABSTRACT:
SUBMITTER: Ciriello G
PROVIDER: S-EPMC4603750 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Cell 20151001 2
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered ...[more]